A refillable microfabricated drug delivery device for treatment of ocular diseases.
نویسندگان
چکیده
An implantable manually-actuated microfabricated drug delivery device was demonstrated as a new approach for delivering therapeutic compounds to ocular tissue in acute in vitro, ex vivo, and in vivo studies.
منابع مشابه
Implantable Mems Drug Delivery Systems for Administration of Unaltered Therapeutic Agents
Drug therapy intervention plays a major role in the management of many ocular diseases. However, precise delivery of pharmaceutical solutions to a specified target within the body is an ongoing challenge in many areas of drug delivery. Current routes of ocular treatment (topical, systemic or intraocular injections) have limited efficacy due to physiological barriers, potential side effects, and...
متن کاملA passive MEMS drug delivery pump for treatment of ocular diseases.
An implantable manually-actuated drug delivery device, consisting of a refillable drug reservoir, flexible cannula, check valve, and suture tabs, was investigated as a new approach for delivering pharmaceuticals to treat chronic ocular diseases. Devices are fabricated by molding and bonding three structured layers of polydimethylsiloxane. A 30 gauge non-coring needle was used to refill the rese...
متن کاملFormulation of Tolmetin Ocuserts As Carriers for Ocular Drug Delivery System
Background: Tolmetin (Tol) is a pyrrole acetic acid derivative that acts as a highly effective topical anti-inflammatory agent. Topical administration of Tol is effective for the management of ocular inflammations.The aim of this study was to formulate and improve a topical ophthalmic delivery system of Tol. Materials and methods: In the present study, ocular inserts of Tol were prepared using ...
متن کاملDesign of eudragit RL nanoparticles by nanoemulsion method as carriers for ophthalmic drug delivery of ketotifen fumarate
Objective(s): Ketotifen fumarate (KF) is a selective and noncompetitive histamine antagonist (H1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. The aim of this study was to formulate and improve an ophthalmic delivery system of KF.Ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...
متن کاملFormulation of Tolmetin Ocuserts As Carriers for Ocular Drug Delivery System
Background: Tolmetin (Tol) is a pyrrole acetic acid derivative that acts as a highly effective topical anti-inflammatory agent. Topical administration of Tol is effective for the management of ocular inflammations.The aim of this study was to formulate and improve a topical ophthalmic delivery system of Tol. Materials and methods: In the present study, ocular inserts of Tol were prepared using ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Lab on a chip
دوره 8 7 شماره
صفحات -
تاریخ انتشار 2008